Microscopy Facility Director
B.S., University of Wyoming (1997)
Ph.D., University of Iowa (2005)
002 Winston Hall
Areas of Interest
Developmental synapse formation, brain-behavior relationships, neural adhesion molecules
Large scale brain organization and function are ultimately dependent upon cell-cell interactions between each pair of communicating cells. The primary aim of my research and scholarship has been to elucidate cellular and molecular mechanisms of synapse formation and stability. How are synapses initially established? What factors regulate development of their strength and stability? How is functional communication between neuronal groups initially formed and maintained? Much of my work has focused on observations of the dynamic activities of neuronal structures during development. My experience during time-lapse confocal imaging has been that early synaptic structures are highly transient, malleable, and adaptive, with progressive maturation balancing rapid reorganization and motility with the need for consistency and order. Understanding factors that control and regulate this balance, as well as the functional importance of dynamic developmental sequences that culminate in mature brain function are therefore subjects of great interest for me.
Holcomb PS, Hoffpauir BK, Hoyson MC, Jackson DR, Deerinck TJ, Marrs GS, Dehoff M, Wu J, Ellisman MH, and Spirou GA. 2013. Synaptic inputs compete during rapid formation of the Calyx of Held: a new model system for neural development. Journal of Neuroscience 33(32):12954-12969.
Yang S, Adhikari S, Dobbala M, Adusumili S, Rowley JD, Ganikhanov F, Zhang L, Marrs G, Wysolmerski R, and Spirou G. 2013. Multi-color ultrafast laser platform for nonlinear optical imaging based on independently tunable optical parametric oscillators. Applied Physics B, Lasers and Optics 111(4):617-625.
Marrs GS, Morgan WJ, Howell DM, Spirou GA, and Mathers PH 2013. Embryonic origins of the mouse superior olivary complex. Developmental Neurobiology 73(5):384-98.
S Ding, X Qiao, J Suryadi, GS Marrs, GL Kucera, U and Bierbach. 2013. Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum. Angewandte Chemie 52:3350-4.
GS Marrs and GA Spirou. 2012. Embryonic assembly of auditory circuits: spiral ganglion and brainstem. Journal of Physiology, 590:2391-408.
AM Benediktsson, GS Marrs, JC Tu, PF Worley, JD Rothstein, DE Bergles, and ME Dailey. 2012. Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia 60:175-188.
ME Dailey, GS Marrs, and D Kurpius. 2011. Maintaining live cells and tissue slices in the imaging setup. Cold Spring Harbor Protocols Online
Hoffpauir, GS Marrs, PH Mathers, and GA Spirou. 2009. Does the brain connect before the periphery can direct? A comparison of three sensory systems in mice. Brain Research 1277:115-129.
GS Marrs, CS Theisen, and JL Brusés. 2009. N-cadherin modulates voltage activated calcium influx via RhoA, p120-catenin, and myosin-actin interaction. Molecular and Cellular Neuroscience 40:390-400.
GS Marrs, T Honda, L Fuller, R Thangavel, J Balsamo, J Lilien, ME Dailey, and C Arregui. 2006. Dendritic arbors of developing retinal ganglion cells are stabilized by b1-integrins. Molecular and Cellular Neuroscience 32:230-241.
L Qin*, GS Marrs*, R McKim and ME Dailey. 2001. Hippocampal mossy fibers induce assembly and clustering of PSD95-containing postsynaptic densities independent of glutamate receptor activation. The Journal of Comparative Neurology 440:284-298. *Authors contributed equally to this work.
GS Marrs, SH Green, and ME Dailey. 2001. Rapid formation and remodeling of postsynaptic densities in developing dendrites. Nature Neuroscience 4:1006-1013.
JD Rose, GS Marrs, C Lewis, and G Schisler. 2000. Whirling disease behavior and its relation to pathology of brainstem and spinal cord in rainbow trout. Aquatic JD Animal Health 12:107-118.
M Dailey, G Marrs, J Satz, and M Waite. 1999. Exploring biological structure and function with confocal microscopy. The Biological Bulletin 197:115-122.
JD Rose, GS Marrs, and FL Moore. 1998. Rapid, corticosterone-induced disruption of medullary sensorimotor integration related to suppression of amplectic clasping in behaving roughskin newts (Taricha granulosa). Hormones and Behavior 34:268-282.