Susan E. Fahrbach

Reynolds Professor of Developmental Neuroscience and Chairperson

The head of apis mellifera

B.A., University of Pennsylvania, 1977
M.A., Oxford University, 1979
Ph.D., The Rockefeller University, 1985

026 Winston Hall
(336) 758-5980
fahrbach@wfu.edu

Areas of Interest

Development of the nervous system, neuroanatomy, social Insects

Research

My laboratory’s research is on the regulation of form (neuroanatomy) and function (physiology) in the nervous system. We use insect models to study how hormones and experience “fine tune” the brain during and after metamorphosis. We use two model systems. The tobacco hornworm moth, Manduca sexta, is our primary model for the study of metamorphosis, and the honey bee, Apis mellifera, is our model for the study of how learning changes the brain. The complex behavior of honey bees allows us to study brain/behavior relationships in a natural, non-laboratory context. Our research tools include immunocytochemistry, classic neuroanatomical methods such as the Golgi technique, and modern molecular approaches including in situ hybridization, quantitative RT-PCR, and the regulation of gene expression in cultures of primary neurons.

Selected Recent Publications

SE Fahrbach. 2013. Developmental Neuroscience: A Concise Introduction. Princeton University Press. 292 pp.

DE Wilson, V Mommaerts RA Velarde, SE Fahrbach, G Smagghe. 2013. Use of primary cultures of Kenyon cells from bumblebee brains to assess pesticide side effects.  Archives of Insect Biochemistry and Physiology 84:43-56.

SE Dobrin and SE Fahrbach. 2012. Visual associative learning in restrained honey bees with intact antennae. PLoS One 7: e37666.

SE Dobrin and SE Fahrbach. 2012. Rho GTPase activity in the honey bee mushroom bodies is correlated with age and foraging experience. Journal of Insect Physiology 58: 228-234.

SE Fahrbach, G Smagghe, and RA Velarde.  2012. Insect nuclear receptors. Annual Review of Entomology 57: 83-106.

SE Fahrbach, JR Nambu, LM Schwartz (2012) Programmed cell death in insects. In: Insect Molecular Biology and Biochemistry, edited by Larry I. Gilbert. Academic Press, pp. 419-449.

JT Jackson, DR Tarpy, and SE Fahrbach. 2011.  Histological estimates of ovariole number in honey bee queens, Apis mellifera, reveal lack of correlation with other queen quality measures. Journal of Insect Science 11:82.

CC Lutz, SL Rodriguez-Zas, SE Fahrbach, and GE Robinson. 2012. Transcriptional responses to foraging experience in the honey bee mushroom bodies. Developmental Neurobiology 72: 153-166.

SE Dobrin, JD Herlihy, GE Robinson, and SE Fahrbach, 2011. Muscarinic regulation of Kenyon cell dendritic arborizations in adult worker honey bees. Arthropod Structure and Development 40:409-419.

SE Fahrbach. 2010. Experimental approaches to hormones and behavior: invertebrates. In Breed, M.D. and Moore, J. (eds) Encyclopedia of Animal Behavior, Volume 1, pp. 686-692. Oxford, Academic Press.

RA Velarde, GE Robinson, and SE Fahrbach. 2009. Coordinated responses to developmental hormones in the Kenyon cells of the adult worker honey bee brain (Apis mellifera L.). Journal of Insect Physiology 55:59-69.

SE Fahrbach and S Dobrin. 2009. The how and why of structural plasticity in the honey bee brain, In: Cognitive Ecology II, edited by Reuven Dukas and John Ratcliffe. University of Chicago Press. Pp. 27-46.

R Weiss, A Dov, SE Fahrbach, and G Bloch. 2009. Body size-related variation in Pigment Dispersing Factor-immunoreactivity in the brain of the bumble bee Bombus terrestris (Hymenoptera, Apidae) Journal of Insect Physiology 55:479-487.

SE Fahrbach and RA Velarde. 2009. Nervous system actions of insect developmental hormones in adult insects. Hormones, Brain and Behavior, Second edition, Elsevier, Oxford, UK. Volume 3, pp. 943-965.

KN Ward, JL Coleman, K Clinnin, S Fahrbach, and O Rueppell. 2008. Age, caste, and behavior determine the replicative activity of intestinal stem cells in honeybees (Apis mellifera L.). Experimental Gerontology 43:530-537.

N Ismail, S Christine, GE Robinson, and SE Fahrbach. 2008. Pilocarpine improves recognition of nestmates in young honey bees. Neuroscience Letters 439:178-181.

SE Fahrbach and S Dobrin. 2009. The how and why of structural plasticity in the honey bee brain, In: Cognitive Ecology II, edited by Reuven Dukas and John Ratcliffe. University of Chicago Press. Pp. 27-46.

SE Fahrbach, JR Nambu, LM Schwartz (2009) Programmed cell death in insect neuromuscular systems during metamorphosis. In: Insect Development: Morphogenesis, Molting, and Metamorphosis, edited by L. I. Gilbert. Academic Press, San Diego, CA.  Pp. 163-196.

KE Himes, KA Klukas, SE Fahrbach, and KA Mesce. 2008. Hormone-dependent expression of fasciclin II during ganglionic migration and fusion in the ventral nerve cord of the moth, Manduca sexta. Journal of Comparative Neurology 509:319-339.