Ronald E. Noftle

Ron NoftleResearch Professor

B.S., 1961, University of New Hampshire
Ph.D., 1966, University of Washington (G. H. Cady)
Postdoctoral Fellow, 1966-1967, University of Idaho (J. M. Shreeve)
Visiting Scientist, 1975-76; U. S. Naval Research Laboratory (W. B. Fox)
Reynolds Research Leave, 1986, 1995, University of Southampton, England (D. Pletcher), 2003,
Los Alamos National Laboratory (T. J. Meyer, J. Schoonover, D. Dattelbaum).
Associate of the WFU Center for Nanotechnology and Molecular Materials.
Recently awarded “Senior Scientist Mentor” by the Camille and Henry Dreyfus Foundation

Prof. Noftle is not taking new graduate students or postdoctoral fellows; he is continuing to work with undergraduate students on research.

Office: Salem 115B
Phone: (336) 758-5520


First row: Kasha Patel, Ron Noftle, Jessica Freyer, Ting JiangSecond row: Kristopher Boyd, Eric Tainsh

Synthesis and Characterization of New Compounds
Prof.  Noftle is interested in the synthesis and characterization of new compounds of  the main group elements particularly those containing fluorine and the elements  of Groups 14-16. These compounds have a wide range of potential industrial and  medical applications including use as charge storage media, solid polymer  electrolytes, ion-exchange media, drug-delivery systems, and molecular  recognition agents. Modern synthetic methods, electrochemistry, spectroscopy  (multi-nuclear NMR, FTIR, GC-MS, and UV-visible), and electron microscopy play  a role in the investigation of these materials. Presently our research is  focused on three projects.

  1. Synthesis of Novel Thiophene Ligands: Our previous work with thiophene imides and amides led to  an interest in the synthesis and characterization of heterocyclic derivatives  bearing functional groups which can act as ligands for metal ions. The  resulting transition metal complexes have applications in electronics, optics  and medicine. The focus of the project involves the synthesis of new thiophene  monomers with chelating side-chains which, when electrochemically polymerized,  can sequester metal ions and act as catalysts or energy-conversion materials.  Since some of these compounds are luminescent, they have potential use as  molecular tags.
  2. Synthesis of Electrically Active Small Molecules: Highly conjugated heterocycles have the potential to act as  electrically conducting thin films and can be tuned by varying the  substituents. These materials could find use in field effect transitors, in  printed circuits, and in organic batteries. This research is being carried out  in collaboration with Prof. Oana Jurchescu of the Wake Forest Physics  Department.
  3. Synthesis and Electrochemistry of Thiophene-Containing  Polymers as Photovoltaic Materials: This research is based on fused-ring systems containing both acceptor and donor  portions which can be polymerized to facilitate exciton dissociation in a  photovoltaic cell. This work is being carried out in collaboration with the WFU  Center for Nanotechnology and Molecular Materials.



Coffin, R. C.; MacNeill, C. M.; Peterson, E. D.; Ward, J.  W.; Owen, J. W.; McLellan, A.; Smith, G. M.; Noftle, R. E.;  Jurchescu, O. D.; Carroll, D. L. Variation of the side chain branch position  leads to vastly improved molecular weight and OPV performance in  4,8-dialkoxybenzo[1,2-b:4,5-b’]dithiophene/ 2,1,3-benzothiadiazole  copolymers.  J. Nanotech. 2011, doi:  10. 1155/2011/572329.

Nie, W.; MacNeill,  C. M.; Li, Y.; Noftle, R. E.; Carroll, D. L.; Coffin, R. C. A Soluble  High Molecular Weight Copolymer of Benzo[1,2-b:4,5-b’]dithiophene and Benzoxadiazole  for Efficient Organic Photovoltaics. Macromolecular. Rapid Comm. 2011, 32, 1163-1168.

MacNeill, C. M.; Peterson, E. D.; Noftle, R. E.; Carroll,  D. L.; Coffin, R. C. A Cyclopentadithiophene/Thienopyrroledione-based  Donor-Acceptor Copolymer for Organic Solar Cells. Synth. Met. 2011, 161, 1137-1140.

MacNeill, C. M.; Day, C. S.; Marts, A.; Lachgar, A.;  Noftle, R. E. Synthesis, Crystal Structure and Properties of Novel  Isostructural Two-Dimensional Lanthanide-Based Coordination Polymers with  2,3,5,6-Tetrafluoro-1,4-benzenedicarboxylic acid. Inorg. Chim. Acta. 2011, 365, 196.

MacNeill,  CM; Day, CS; Gamboa, SA; Lachgar, A.; Noftle, RE.  Solvothermal and reflux          syntheses,  crystal structure and photoluminescence. Properties of lanthanide-thiophene-dicarboxylate-based  metal-organic frameworks,  J.Chem. Crystallogr. 2010, 40, 222-230.

Synthesis, structure, and electrochemistry of  N-(3-thenoyl)fluoro-sulfonimide and bis(2-thenoic)imide. Preparation of polymers containing the fluorosulfonimide group, MacNeill, CM; Dai, J; Day, CS; Lazar, SP; Howell, SJ; Noftle, RE. Synth. Metals. 159 (2009)1628-1635.

Bis(μ-dithieno[3, 2-b:2’, 3’-d]thiophene-2, 6-dicarboxylato-κ2O2:O6)bis[bis(1, 10-phenanthroline-κ2N, N’)cobalt(II)]dimethylformamide disolvate, MacNeill, CM; Day, CS; Noftle, RE. Acta Cryst. E65 (2009) m486.

Solvothermal and reflux syntheses, crystal structure and photoluminescence. Properties of lanthanide-thiophenedicarboxylate-based metal-organic frameworks, MacNeill, CM; Day, CS; Gamboa, SA; Donaldson,M.; Lachgar, A.; Noftle, RE. J.Chem. Crystallogr. DOI 10.1007/s10870-009-9638-5.

Metal  complexes of 3-thiophene carboxamides containing a pyridine ring,            Howell, S. Jarrett; Day, Cynthia S.; Noftle, Ronald E. Inorg. Chim. Acta,  2007, 360, 2669.

Synthesis and Characterization of 3-Thiophene Carboxamides Containing a Pyridine Ring: Structure, Electrochemistry, and Complexation, Howell, S. J.; Day, C. S.; Noftle, R. E. Inorganica Chimica Acta, 2005, 358, 3711-3723.

Synthesis and structural characterization of 3-thienyl alkyl imides, Dai, J.; Day, C. S.; Noftle, R. E. Tetrahedron, 2003, 59, 9389-9397.

An Efficient Method for the Synthesis of 3-Alkylthiophenes Bearing Functional Groups: Imides and Amides, Dai, J.; Sellers, J.L.; Noftle, R. E. Synthetic Metals, 139, 2003, 81-88.

Stoichiometric Preference in Copper-promoted Oxidative DNA Damage by Ochratoxin A. Manderville, R. A.; Calcutt, M. W.; Dai, J.; Park, G.; Gilman, I. G.; Noftle, R. E.; Mohammed, A. K.; Dizdaroglu, M.; Roderiguez, H.; Akman, S. A. J. Inorganic Biochemistry, 2003, 95, 87-96.

Influence of the A-Ring on the Redox and Nuclease Properties of the Prodigiosins: Importance of the Bipyrrole Moiety in Oxidative DNA Cleavage, Melvin, M. S.; Calcutt, M. W.; Noftle, R. E.; Manderville*, R. A. J. Chem Res. Toxicol. 2002, 15, 742-748.

Electrochemical Oxidation of Ochratoxin A: Correlation with 4-Chlorophenol, Calcutt, M. W.; Gilman, I. G.; Noftle*, R. E.; Manderville*, R. A. J. Chem. Res. Toxicol., 2001, 14, 1266-1272.

Characterization and Crystal Structures of Some Fluorinated Imides, Narula, P. M.; Day, C. S.; Odian, M. A.; Pennington, W. T.; Lachgar, A.; Noftle, R. E. Polyhedron, 1999, 18, 1751-1759.