Dilip K. Kondepudi

Dilip K. Kondepudi

Contact Info


Associate Chair
Thurman D. Kitchin Professor

B.Sc. 1971, Madras University
M.Sc. 1973, Indian Institute of Technology, Bombay
Ph.D. 1979, University of Texas at Austin (Ilya Prigogine, Nobel Laureate)

AAAS Fellow

– Visiting Professor, summer of 1985, The Solvay Institute, Brussels
– Fellow, Japan Society for Promotion of Science, 2000-2001
– Visiting Professor, Keio University, Yokohama, Japan. June, 2003.
– Visiting Professor, Institut Carnot de Bourgogne, UMR 5209 CNRS-Université de Bourgogne, France, Summers, 2004-2008
– Ranlet and Frank Bell Jr. Faculty Fellowship, 2011-13

Office: Salem 204
Phone: (336) 758-5131
Email: dilip@wfu.edu

Research Description

Research Description & Information

A general theory of spontaneous chiral symmetry breaking in chemical systems has been formulated. The fundamental equations of this theory depend only on the two-fold mirror-image symmetry and not on the details of the chemical kinetics. Close to equilibrium, the system will be in a symmetric state in which the amounts of the two enantiomers of all chiral molecules are equal. When the system is driven away from equilibrium by a flow of chemicals, a point is reached at which the system becomes unstable to small fluctuation in the difference in the amount of the two enantiomers. As a consequence, a small random fluctuation in the difference in the amount of the two enantiomers spontaneously grows and the system makes a transition to an asymmetric state. The general theory describes this phenomenon in the vicinity of the transition point. –READ MORE–




Modern Thermodynamics: From Heat Engines to Dissipative Structures
Dilip Kondepudi and Ilya Prigogine

First edition 1998

First edition 1998

Second Edition 2015

Second Edition 2015





























Introduction to Modern Thermodynamics
Dilip Kondepudi

 Published 2008

Published 2008








Most Cited Publications

Articles on Chiral Asymmetry

“Chiral Symmetry Breaking in Sodium Chlorate Crystallization”, D.K. Kondepudi, R. Kaufmann and N. Singh, Science 250 (1990) 975 – 976. Citations > 500

” Weak Neutral Currents and the Origin of Biomolecular Chirality” D.K. Kondepudi and G.W. Nelson, Nature, 314 (1985) 438 – 441. Citations > 270

“Chiral Autocatalysis, Spontaneous Symmetry Breaking, and Stochastic Behavior”, Kondepudi, D.K. Asakura, K, Accounts of Chemical Research, 34(2001) 946-954. Citations > 170

“Chiral Symmetry Breaking in Stirred Crystallization of 1,1′- Binaphthyl Melt”, Kondepudi, D.K., Asakura, K. and Laudadio, J., J. Am. Chem. Soc. 121 (1999)1448-1451. Citations > 120

“Chiral Symmetry Breaking in Nonequilibrium Systems”. Kondepudi, D. K. and Nelson, G.W., Phys. Rev. Lett. 50 (1983) 1023 – 1026. Citations > 120

” Kinetics of Chiral Symmetry Breaking in Crystallization” D. K. Kondepudi, K. L. Bullock, J.A. Digits, J.K. Hall and J. Miller, J. Am. Chem. Soc. 115 (1993) 10211-10216.   Citations > 100

“Chiral Symmetry Breaking states and Their Sensitivity in Nonequilibrium Systems” D. K. Kondepudi, G.W.Nelson, Physica 125A (1984) 465 – 496. Citations > 90

“The Handedness of the Universe” (Invited article) R. A. Hegstrom and D. K. Kondepudi, The Scientific American, 262 ( Jan. 1990) 108 – 115. Citations > 75

Review Article: “Emergence of homochirality in far-for-equilibrium systems: mechanisms and role in prebiotic chemistryz” Plasson, R., Kondepudi, D.K., Bersini, H., Commeyras, A., Asakura, K. Chirality 19 (2007) 589-600. Citations > 65

“Stirring Rate as a Critical Parameter in Chiral Symmetry Breaking Crystallization” K. Kondepudi, K.L. Bullock, J.A. Digits, P.D. Yarborough, J. Am. Chem. Soc. 117 (1995) 401-404. Citations > 60

“Selection of Molecular Chirality by Extremely Weak Chiral Interactions Under Far-From-Equilibrium Conditions” (Proc. of Symposium on Chiral Symmetry Breaking in Physics, Chemistry and Biology, Rouen, 1986) D. K. Kondepudi, Biosystems, 20 (1987) 75 – 83. Citations > 47

“Chiral Symmetry Breaking in Crystallization: The Role of Convection” Buhse, T., Kondepudi, D.K. , Durand, D., Laudadio, J., Spilker, S. Phys. Rev. Lett. 84 (2000) 4405-4408. Citations > 40

Articles on Thermodynamics of Nonequilibrium Systems

“Sensitivity of Nonequilibrium Systems”, D. K. Kondepudi and I. Prigogine, Physica 107A (1981) 1 – 24. Citations > 75

” Sensitivity of Nonequilibrium Chemical Systems to Gravitational Field” D.K. Kondepudi, I. Prigogine Adv. in Space Res. Vol. 3, No. 5 (1983) 171 -176. Citations > 60

Publications since year 2000.

D.K. Kondepudi, B. Kay, and J. Dixon “End-directed evolution and the emergence of energy-seeking behavior in a complex system” Phys. Rev. E., Rapid Communication. (2015) to appear

K. Kondepudi, Book Review for Chirality. Biochirality: Origins, Evolution and Molecular Recognition. Pedro Cintas, Editor. Chirality DOI: 10.1002/chir.22336, 2014

K. Kondepudi, “Chemical Thermodynamics” Chapter 1126, pp. 1-10 Encyclopedia of Sciences and Religions,   A. Runehov & L. Oviedo (eds.), ,
DOI 10.1007/978-1-4020-8265-8, (Springer Science+Business Media, Dordrecht 2013)

K. Kondepudi, “Self-Organization, Entropy Production and Physical Intelligence: Preliminary Remarks” Ecological Psychology, 24 (2012) 33-45.

K. Kondepudi, “Thermodynamic Stages in the Evolution of a PI System” White paper written for HRL Labs for a DARPA Project on Physical Intelligence. June, 2011

K. Kondepudi, “Self-Organization, Entropy Production and Physical Intelligence 1” White paper written for HRL Labs for a DARPA Project on Physical Intelligence. July, 2010.

Baras, D.K. Kondepudi and F. Bernard , Combustion synthesis of MoSi2 and MoSi2-Mo5Si3 composites: multilayer modeling and control of the microstructure Journal of Alloys and Compounds 505(2010) 43-53     http://dx.doi.org/10.1016/j.jallcom.2010.06.024.

Fisher, A., Pagni, R.M., Compton, R.N. Kondepudi, D.K. Laser Induced Crystallization, in Nanoclusters , Purusottam J. and Castleman, A. (Ed) VIII. Clusters and Assemblies (Elsevier, Amsterdam, New York, Scheduled for publication 2010, ISBN-13: 978-0-444-53440-8 )

Kondepudi, D.K., and Kapcha, L., Entropy Production in Chiral Symmetry Breaking Transitions, Chirality 20 (2008) 524-528

Baras, F., Kondepudi, D.K., A multilayer model for self-propagating high-temperature synthesis of intermetallic compounds J. Phys. Chem. B, 111(2007) 6457-6468; Web; (Article) DOI: 10.1021/jp066776p

Plasson, R., Kondepudi, D.K., Bersini, H., Commeyras, A., Asakura, K. Review Article: Emergence of homochirality in far-for-equilibrium systems: mechanisms and role in prebiotic chemistry Chirality 19 (2007) 589-600

Kondepudi, D.K. Thermodynamics, Symmetry and Chirality Symmetry: Culture and Science Vol. 16 (2005)351-364

Asakura, K., Plasson, R,, and Kondepudi, D.K. Experimental evidence and theoretical analysis for chiral symmetry breaking in growth front of conglomerate crystal phase of 1,1′-binaphthyl Chaos 16 (2006) 037116-1 to 037116-7

Kondepudi, D.K. Asakura, K. Chiral Asymmetry in Nature, in Chiral Analysis (chapter 2) ) Eds. Kenneth W. Busch and Mariana A. Busch (Elsevier, 2006)

Plasson, R., Kondepudi, D.K., and Asakura, K. Three-Dimensional Description of the Spontaneous Onset of Homochirality on the Surface of a Conglomerate Crystal Phase, J. Phys. Chem. B 110 (2006) 8481-8487

Kondepudi, D.K., and Crook, K. Theory of Conglomerate Crystallization in the Presence of Chiral Impurities, Crystal Growth and Design 5 (2005) 2173-2179.

Asakura, K., Yamamoto, T., Inoue, S., Osanai, S., Kondepudi, D.K., Yamaguchi, T. A new perspective on the mechanism of asymmetric amplification, Chemical Physics Letters 406 (2005) 312-317.

Kouichi Asakura, Yasushi Nagasaka, Shuichi Osanai, and Dilip K. Kondepudi, “Kinetic Model for Chiral Symmetry Breaking Transition in Growth Front of Conglomerate Crystal Phase” J. Phys. Chem. B, 109 (2005), 1586-1592.

Kondepudi, D.K., Chapter 13″Theory of Hierarchical Homochirality” Invited article” Progress in Biological Chirality”, Ed. G. Palyi, C. Zucchi and L. Caglioto (Elsevier, 2004) pp 159-171.

Kondepudi, D.K., “Spontaneous Generation and Propagation of Chiral Asymmetry”, Invited article, International Journal of Quantum Chemistry, 97 (2004) 222-227.

Kouichi Asakura, Yasushi Nagasaka, Masashi Hidaka, Masato Hayashi, Shuichi Osanai, Dilip K. Kondepudi “Chiral symmetry-breaking transition in growth front of crystal phase of 1,1-binaphthyl in its supercooled melt” Chirality 16, (2004) 131-136.

  1. K. Kondepudi “Theory of hierarchical chiral asymmetry” Invited articleMendeleev Communications 13 (2003) 128-129

Daniel J. Durand, Dilip Kondepudi, Paulo F. Moreira Jr and Frank H. Quina “Generation of Molecular Chiral Asymmetry Through Stirred Crystallization” Chirality, 14 (2002) 284-287

Kondepudi D.K. Chapter 21 “Chiral Autocatalysis and Selectivity in the Vicinity of Solid Surfaces” in Chirality: Physical Chemistry, J.M. Hicks (Ed) (2002)ACS Symposium 810. pp. 302-318

Kondepudi D.K. Asakura, K., Soga, T., Uchida T., and Osanai, S, “Probability Distribution of Enantiomeric Excess in Unstirred and Stirred Crystallization of 1,1’-Binaphthyl Melt”, Chirality, 14(2002) 85-89

Kondepudi, D.K., Buhse, T., “Hasards et Réactions Chimiques de Non-Équilibre” in L’Homme Devant L’Incertain, Ilya Prigogine (Ed), (2001), Editions Odile Jacob, Paris.

Kondepudi, D.K. Asakura, K. “Chiral Autocatalysis, Spontaneous Symmetry Breaking, and Stochastic Behavior”, Accounts of Chemical Research, 34(2001) 946-954.

Kouichi A., Kondepudi, D.K., K., Osanai, S. ” Conditions for Chiral Asymmetry Generation in the Preparation of the Chiral Octahedral Cobalt Complex”, Chirality 13(2001)435-440

Kondepudi, D. K., Durand, D.J. “Chiral Asymmetry in Spiral Galaxies?” Chirality 13(2001) 351-356

Guy Dewel, Dilip Kondepudi and Ilya Prigogine, Chapter 16 “Chemistry Far From Equilibrium” (in New Chemistry, N. Hall (Ed) (2000) Cambridge Univ. Press, New York. pp. 440-464.

Asakura, K., Kondepudi, D.K., Kurihara, K., Ikumo, A., Tanaka, A., Miura, T., Ozawa, T, Kushibe, Y. and Osanai, S. “Chirally Autocatalytic Reactions Performed in Highly Supersaturated Condition”, Proceedings of the Symposium Macromolecular Symposium, 160 (2000) 7-13.

Buhse, T., Kondepudi, D.K. , Durand, D., Laudadio, J., Spilker, S. “Chiral Symmetry Breaking in Crystallization: The Role of Convection” Phys. Rev. Lett. 84 (2000) 4405-4408


Asakura, K., A. Ikumo, K. Kurihara, S. Osanai, and D.K. Kondepudi, Random chiral asymmetry generation by chiral autocatalysis in a far-from-equilibrium reaction system. Journal of Physical Chemistry A, 104 (2000), p. 2689-2694.


Awards & Accomplishments

Thurman D. Kitchin Professor of Chemistry
Ranlet and Frank Bell, Jr. Faculty Fellowship 2011-2013
Excellence in Entrepreneurship Award, Center for Creativity, Innovation and Entrepreneurship 2011
AAAS Fellow 2009
Excellence in Entrepreneurship Award, Office of Entrepreneurship and Liberal Arts 2008